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Finally, although POU2F3 or FOXI1 KO severely dysregulated ion transport in ALIs, these cultures robustly retained CFTR activity, as measured by enhanced voltage response to forskolin/IBMX stimulation and CFTR(inh)172 inhibition treatments in KO cultures relative to controls (Fig

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Patients with SMI tend to smoke more regularly, display patterns of heavy smoking, extract more nicotine and carbon monoxide from each cigarette, and develop severe nicotine dependence

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